define disinfectant
kills bacteria from the area e.g. instrument
reduces bacteria being transferred from environment to patient
define antiseptic
applied to the skin and wounds
kill bacteria and reduce the likelihood of wounds becoming infected , bacteria getting into the blood
define an antibiotic
a chemical substance produced by a microorganism which has the capacity to inhibit the multiplication/replication of bacteria and other microorganisms
how do antibiotics work
slow bacterial growth/replication so fewer cells are produced
gives more time for immune system to respond
expansion of B cells, produce antibodies
by phagocytosis, macrophages engulf and digest bacteria
how do antibiotics work
inhibit bacterial cell wall synthesis (cell lysis)
disruption of the cell membrane (cell lysis changes permeability)
inhibition of nucleic acid synthesis, replication and transcription (prevents cell division or enzyme synthesis)
inhibition of protein synthesis
inhibition of bacterial metabolic enzymes
what are the two groups saying bacteria can be classed in
bactericidal antibiotics
bacteriostatic antibiotics
what do bactericidal antibiotics do
will destroy almost all of the pathogens present
what do bacteriostatic antibiotics do
antibiotic or the dose completely inhibits the replication of the microorganism
hosts immune system can then destroy the pathogen
why do antibiotics not destroy animal cells or viruses
antibiotics that weaken the cell walls do not work against animal cells or viruses because the cells don’t have cell walls
antibiotics that disrupt cell membranes do not work against viruses because they have no cell membrane
antibiotic resistance process
random mutation has caused advantageous allele, makes bacteria naturally resistant
advantageous allele may produce an enzyme to break down antibiotic
antibiotic acts as a selection pressure
resistant bacteria survive and reproduce by binary fission
pass resistant allele to offspring
increased allele frequency for resistance in allele population
antibiotic is no longer effective
how do hospitals control the development of multi-drug resistant bacteria and their spread
hygiene- hand wash stations at ward entrances
clothing- no ties, watches or long sleeves
only use antibiotics when patient has been 100 percent diagnosed with bacterial infection
only use antibiotics when needed
patients should complete cycle even if they fell better to ensure all bacteria is destroyed
infection control used to prevent spread in hospitals by isolating patients
give antibiotic that targets bacteria causing infection
educate patients to take antibiotics