Apoptosis

Question 1

Excecution phase of apoptosis

Answer 1

executioner caspases such as caspase 3 and 6

Question 2

2 pathways of apoptosis

Answer 2

1. MItochondrial(intrinsic) pathway
   [more common]
2. Death receptor(extrinsic)
   pathway

Question 3

Clinico pathological corelation of APOPTOSIS in health and disease

Answer 3

growth factor deprivation.
hormone sensitive cells are deprived of relevant hormones, lymphocytes that are not stimulated

Question 4

failure of protein foldin

Answer 4

excess misfolded proteins due to
. metabolic stress
. genetic mutation in oroteins
. viral infections
causes ER stress, failure of adaptation
causing apoptosis.

Question 5

Pathological correlation of apoptosis balance??

Answer 5

Autoimmune diseases happen,
when defected apoptosis.
(body targets its own cells)

Neurogenerative diseases due to increase apoptosis

neuclasia

Question 6

caspases and executioner phase of apoptosis?
procaspase 8, …..?
antiapoptotic proteins?
phagocytic takeup of cell
soluble factors, phosphatidyl serine proteins,
implication nuclasea, neurogenerative, autoimmune.

Answer 6

…