1
Q
Markers of apoptosis
A
Annexin V interacts with phosphotidal serine
Fluoresceses
TUNEL-detects strand breaks as they happen
DNA Laddering- splits at 180-185 intervals
Caspase cleavage
2
Q
P53 in unstressed cells
A
UB’d by MDM2 (HDM2)
3
Q
P53 in damaged cells
A
N terminus activation by MAPK, p14ARF
4
Q
BCL-2
A
Anti-apoptotic marker that blocks membrane in cytoplasm
5
Q
Bad, Bid, Bax
A
Pro apoptotic molecules that work to open up the mitochondria and allow cytochrome C leakage
6
Q
Initiator caspases
A
2, 9 intrinsic
8, 10 extrinsic
7
Q
Executioner caspases
A
3, 6, 7
8
Q
DR4, DR5
A
Pro apoptotic receptors
Initiate extrinsic pathway through binding of ligand
9
Q
Procaspase 8, 10
A
Move Bid to the mitochondria
FINAL Biomedical Sciences
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