ECM

Question 1

Structure of collagen

Answer 1

Triple a helix in pattern of Gly-X-Y, assembled outside of cell
I-bone, tendons, ligaments   --(90%)
II-cartilage
III-skin
IX- used to associate type II fibrils

Question 2

Other collagen Types

Answer 2

IV- sheet like network under cells
VII- anchoring network
XVII-collagen anchoring filaments

Question 3

Elastin

Answer 3

Assembled outside of cell

Fibrillin polymer

Question 4

Glyocosaminoglycans

Answer 4

Bind water and resist compression

Question 5

Proteoglycans

Answer 5

Mechanical support

Question 6

Aggrecan

Answer 6

Cartilage

Question 7

Perlecan

Answer 7

Uses heparin sulfate in Basel lamina

Question 8

Syndecan

Answer 8

Fibroblast and epithelial cell surface

Example of connection between ECM and signaling pathways

Question 9

Integrins

Answer 9

Bind actin cytoskeleton and organize signaling molecules

Question 10

Integrin activation

Answer 10

Signal receptor binds with Ligands
Causes conformational change in integrin to active state
B2- lymphocyte
B3- platelet