G1 Cdk
Puts cell past restriction point
G1/S Cdk
Commits the cell to replication
S Cdk
Initiates replication
Binds and dissociates ORC by phosphorylation Cdc6
This also prevents re-replication
M Cdk
Promotes mitosis
Activated by Cdc25 and CAK
Inhibited by Wee1
APC
Ub’s M-CyclinCdk
CKI
P27 protein that inhibits cyclin-Cdk
E2F
TF for S-cyclin
Rb Protein
Inhibits E2F
p53 at g1 damage checkpoint
Expresses CKI, which then binds Cyclin-Cdk