NAPLEX > arrhythmia > Flashcards

arrhythmia Flashcards

(45 cards)

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1
Q

antiarrythmics that cause qtc prolongation

A

class I (especially Ia, also flecainide)
class III ( amiodarone, sotalol)

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2
Q

abx that cause qtc prolongation

A

FQ
macrolides
aminoglycosides

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3
Q

Azoles that cause qtc prolongation

A

all except isavuconazonism

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4
Q

antidepressants that cause qtc prolongation

A

TCA
SSRIs (sertraline preferred)
SNRI
mirtazapine
trazodone

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5
Q

antiemetics that cause qtc prolongation

A

5ht3 receptor antagonist (ondansetron)
droperidol
phenothiazine

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6
Q

antipsychotics that cause qtc prolongation

A

most of them; -pines, -dones, -zines

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7
Q

diuretics that cause qtc prolongation

A

mild on its own, but worse coupled with electrolyte depletion and additive qtc meds

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8
Q

other drugs that cause qtc prolongation

A

donepezil
methadone
tacrolimus
fingolimod
PIs

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9
Q

depolarization =

A

contraction

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10
Q

repolarization +

A

relaxation

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11
Q

class Ia intermediate

A

disopyramide
quinidine
procainamine

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12
Q

Class Ib

A

lidocaine
mexiletine

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13
Q

Class Ic

A

flecainide
propafenone

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14
Q

Class effect of class Ia-Ic

A

pro arrhythmic
(-) inotropic potential

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15
Q

what effect does disophyramide have

A

anticholinergic (anti-SLUD)

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16
Q

Quinidine notes

A

take w F
hemolysis (avoid in decrease G^PD) + combs test

DILE
diarrhea
cramping
cinchonism OD (tinnitus, blured vision, HA, delirium)

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17
Q

Procainamide notes

A

injection
level 4-10 mcg/mL
BBW agranulocytosis
long term use: antinuclear antibody (ANA)–> DILE

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18
Q

Lidocaine notes

A

injection

for refractory vT ( no effect in Afib)

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19
Q

Flecainide is CI in

20
Q

Propafenone notes

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A

taste disturbances (metallic taste)

CI: MI & HR

21
Q

Class II

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A

BB
- metroprol
- esmolol
- atenolol

22
Q

Class III

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A

Dronedarone
Dofetilide
Sotalol
Ibutilide
Amiodarone

23
Q

primarily inhibit K+ channels

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A

amiodarone and dronedarone

24
Q

preferred in HF + Afib

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A

amiodarone & dofetilide

25
BBW for dronedarone
risk of dreath, stroke , & HF in those with decompensated HF or permanent afib liver failure, pulmonary fibrosis, SE: QT prolongation
26
Dofetilide
must have continuous ECG monitoring ability to monitor circle >3days pro arrhythmic DOC: in HF
27
sotalol
inhibit K+ channels nonselective BB
28
Ibutilide
Injection Correct low K+ and Mg prior to and during therapy
29
Amiodarone SE
lung/ liver/ eye damage hyper/hypothyroidism photosensitivity skin discoloration (blue-grey) avoid grapefruit iodine hypersensiti
30
Class IV
verapamil diltiazem avoid in HFrEF
31
IV Infusions of amIODarone require
non PVC container (polyolefin/glass) 0.22 micron filter central line preferred
32
what brand of amiodarobe comes in a non pvc container
Nexerone
33
half life of amiodarone
40-60 days
34
amiodarone inhibits
2C9 2D6 3A4 PgP RENAL ELIMINATION OF MANY DRUGS
35
when starting amiodarone
decrease digoxin by 50% decrease warfarin by 30-50% simvastatin 20 mg/day lovastatin 40 mg/day
36
do not use this medication with amiodarone bc enhances bradycardia effect
sofbuvir
37
amiodarone in combo with BB & CCB increase risk of
decrease HR
38
digoxin is usually given with BB or non DHP CCB for
rate control
39
antidote for digoxin
digifab
40
tx range for digoxin in a fib
0.8-2 ng/ml
41
digoxin and circle < 50
decrease dose or freq
42
digoxin IV:PO
decrease by 20-25%
43
used for PSVTs
adenosine do not use for Tach or cardio version T1/2= < 10 seconds
44
digoxin
n/v loss of appetite bradycardia blurred vision/ double vision greens yellow halo around light and object
45
these drugs are associated with DILE
quinidine procainamide
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