HTN

Question 1

drugs that increase BP

Answer 1

stimulants: ADHD drugs, decogenstants , recreational sub (coffee/cocaine), antidepressants

agents that increase salt and water: NSAIDS, cyclosporine, steroids

EPOA

oral contraceptives

VEGF inhibitors

Question 2

stage 1 hypertension

Answer 2

130-139/OR 80-89

Question 3

stage 2 htn

Answer 3

> 140/ OR >90

Question 4

tx for elevated BP

Answer 4

life style mod

Question 5

tx for stage 1 + Clinical ASCVD or risk >10%

Answer 5

pharm tx

Question 6

tx for stage 1 no Clinical ASCVD or risk >10%

Answer 6

lifestyle mod

if not at goal at 6 mon add pharm tx

Question 7

tx for stage 2 htn

Answer 7

pharm tx

Question 8

Goal BP

Answer 8

<130/80

Question 9

preferred tx for black w/o ckd

Answer 9

thiazide or dhp CCB

Question 10

preferred tx for ckd

Answer 10

acei or arb

stage 3 CKD: eGFR < 60ml/min or
albuminuria: >30mg/day

Question 11

when to start two drugs from preferred class

Answer 11

average baseline is >20/ 10 mmHg above goal

ex: 150/90 mmHg

Question 12

htn meds to be avoided in pregnancy

Answer 12

ace, arb, direct renin inhibitors

Question 13

first line htn med for pregnancy

Answer 13

labetalol, nifedipine er (preferred)

methyldopa

Question 14

when should drug tx be started in pregnancy

Answer 14

> 140/ or >90

Question 15

severe htn in preg

Answer 15

> 160/ or >110

Question 16

tx in preg for severe htn

Answer 16

iv labetalol or hydralazine

if no iv access: nifedipine IR

Question 17

where does thiazides work

Answer 17

DCT

Question 18

SE of thiazides

Answer 18

increase K, mg, na
increase ca, UA, LDL, TG, BG
photosensitivity

Question 19

thiazides + lithium

Answer 19

thiazides decrease renal clearance of lithium and increase lithium toxicity

decrease litium dose

Question 20

thiazides and dofetilide

Answer 20

do not use in combo, qt prolongation

Question 21

DHP CCB MOA

Answer 21

more selective for vascular smooth muscle

causes peripheral arterial vasodilation

Question 22

DHP CCB SE

Answer 22

peripheral edema
ha
flushing
palpitations reflextachycardia
gingival hyperplasia

Question 23

do not use nifedipine IR for

Answer 23

chronic hypertension or acute BP reduction in non pregnant adults

Question 24

which DHP CCB is safe in HF

Answer 24

amlodipine

Question 25

clevidipine (injection)

Answer 25

ci if allergy to soy bean, or egg cause hypertrigyceridemia use ascetic technique to prevent infection 12 hr use after vial open

Question 26

NON- DHP CCB MOA

Answer 26

more selective for the myocardium negative ion topic negative chronotropic

Question 27

NON- DHP CCB SE

Answer 27

constipation, gingival hyperplasia, edema

Question 28

all CCB are ______ except clevidipine

Answer 28

substrates of cyp3a4

Question 29

BBW of RAAS drugs

Answer 29

can cause injury and death to fetus, d/c as soon as pregnancy detected

Question 30

ACE / ARB SE

Answer 30

angio edema, hypokalemia, renal impairment, hypotension, cough less with ARBS

Question 31

was out period w entresto

Answer 31

only with ace, 36 hrs

Question 32

potassium sparing diuretics BBW

Answer 32

hyperkalemia

Question 33

Potassium sparing diuretics SE

Answer 33

hyperkalemia, increase Scr, dizziness,

Question 34

CI of Potassium sparing diuretics

Answer 34

hyperkalemia, severe renal impairment, addisons dx (spironolactone)

Question 35

strong cyp3a4 potassium sparing d

Answer 35

eplerenone

Question 36

bb used in hf

Answer 36

carvedilol, bisoprolol, metoprolol succinate