ASC

Question 1

3 characteristics

Answer 1

1. long-term renewable
   - identical copies of themselves for long period of time
2. giving rise to fully differentiated cell that has mature phenotypes
   - capable of differentiated function
3. clonogenic
   - single-> colony of genetically identical cells

Question 2

Sources?

Answer 2

1. umbilical cord
2. placenta
3. specialised tissues and organs

Question 3

Define plasticity

Answer 3

ability of ASCs to become other cell types

Question 4

Define transdifferentiation

Answer 4

change crosses a germline barrier

Question 5

an eg?

Answer 5

Haematopoietic

• multipotent-> several cell types
• > replenishing blood and regenerating immune system
  eg: RBC, WBC, platelets

Question 6

3 advantages

Answer 6

1. sufficient
2. do not req’ environmental manipulations
   - px specific cell types that they are found in
3. lower rejection risk
   - > isolated from patient’s body

Question 7

4 disadvantages

Answer 7

1. limited in quantity
   - tiny no-> diff to ID and plurify
   - disperse throughout the body
2. can only dy/dx into limited cell types
   - > multipotent
3. cannot divide indefinitely
4. limited in ability to dy/dx