Differentiating Stem Cell

Question 1

When is differentiation occurring

Answer 1

1. specific growth factors bind to CS receptors
   - > initiate cell signalling pathway
2. specific inhibitory growth factor bind to CS receptors
   - > extracellular signals cause differentiation into other types

Question 2

Two types of signals and their how

Answer 2

1. Internal
   - certain genes become activated/inactivated
   - >differentiated cell develops structures and performs certain f(n)
2. External
   - chemicals secreted by other cells
   - physical contact with neighbouring cells
   - certain molecules in microenvironment

Question 3

What are the stimulus req’ for the dy/dx of ESC?

Answer 3

eg: growth factors, cyclins (+CDK)
- px sufficient ATP, enzymes, protein
- DNA replication, mitosis