1
Q
Types of tumor antigens (2)
A
- tumor specific antigens (TSA)
- tumor associated antigens
2
Q
Where do we find TSA?
A
only on tumor cells, not in the normal organism
3
Q
What are TSAs?
A
mostly mutated oncoproteins or proteins of tumor suppressor genes
4
Q
Examples of TSA
A
The abnormal products of RAS, p53…
5
Q
Where can we find TAA?
A
On tumor cells and on other non-neoplastic cells
6
Q
What are TAA good for?
A
- diagnostic
- vaccination
- treatment
7
Q
Why do TAA evoke weaker immune reaction?
A
because of immune tolerance over time
8
Q
Examples of TAA (6) tumor associated antigens
A
- overexpressed cellular Ags
- Oncospermatogonal Ags
- Oncofetal Ags
- Tumor antigens produced by viruses
- Cell surface glycoproteins
- cell type specific differentiation antigens
9
Q
Example of overexpressed cellular ag
A
PSA (prostate specific antigen)
10
Q
Example of oncospermal antigens
A
cancer testis antigens : MAGEA1
11
Q
Example of cell surface glycoprotein that acts as tumor antigen
A
ganglioside - melanoma
