1
Q
2 anti-tumor effector mechanisms
A
- via cell mediated immunity
- via humoral immunity
2
Q
Cell-mediated immunity anti-tumor mechanisms?
A
- sensitized cytotoxic T cells
- NK cells
- Macrophages
3
Q
Which T cells can kill tumor cells directly?
A
MHC restricted CD8+ T cells
4
Q
Which cells can NK cells attack? (2)
A
- cells that do not express MHCI antigen
- cells that have stress-induced antigens that can bind to NKG2D receptor
5
Q
Which macrophages have cytotoxicity against tumor cells?
A
M1 macrophages
6
Q
Example of humoral mechanism against tumors?
A
Giving CD20 against non hodgkin lymphomas
7
Q
Escape mechanism theories? (5)
A
- selective outgrowth of antigen negative variants
- loss / reduced MHCI expression
- immunosuppression by tumor cell products
- antigen masking
- apoptosis of cytotoxic T cells
8
Q
How can tumors cause immunosuppression? (2)
A
- TGF beta overproduction
- Activation of T reg cells
