Von Willibrand Factor Deficiency
In 50% of the pts, the PTT is prolonged
PT normal
AD inheritance
Vit K deficiency
Severe cases with prolonged PT and PTT
Elevated PIVKA (Protein Induced by Vitamin K Absence or Antagonist-II)
Hemophilia A
Factor VIII deficiency, X-linked recessive
PT NORMAL
PTT Prolonged
Hemophilia B
Factor IX deficinecy, X-linked
PT NORMAL
PTT prolonged
Factor XIII deficiency
PT and PTT normal
(Fibrin clot issue, common pathway)
Autosomal
Intrinsic pathway factors
Assess with PTT
XII
XI
IX
VIII
Extrinsic Pathway
Tissue factor (III)
VII
Assess with PT
Common coag pathway
X
Prothrombin (II) -> Thrombin
Fibinogin (I) -> Fibrin clot (XIII)
Common bleeding lab results in case of AHT
Anemia
Elevated PT
PT is elevated becuase of releast of thrombophilin which activates the extrinsic pathway
What factor can be elevate by stress?
Factor VIII
What bleeding lab can be falsey low in the neonatal period?
Fibrinogin
Normal newbown PT
16 (12- 23)
Adult slightly lower at 12
Normal newborn PTT
44 (35 - 52)
