Bone Disease

Question 1

Paget disease

Answer 1

⬆️osteoclasts
⬆️osteoblasts

Mosaic pattern of woven and lamellar bone

Question 2

Vitamin D deficiency

Answer 2

Osteoid matrix accumulation around trabecula.

Low urinary Ca+

Question 3

Osteopetrosis

Answer 3

Persistence of the primary spongiosa in the medullary cavity with no mature trabeculae.
⬇️ osteoclastic bone reabsorption resulting in accumulation of woven bone and diffuse skeletal thickening.

Question 4

Osteoporosis

Answer 4

Trabecula thinning with fewer interconnections