Buprenorphine

Question 1

Mechanism of Action

Answer 1

Partial agonist at mu receptors, antagonist at kappa receptors.

Question 2

Indications

Answer 2

• Relief of moderate to severe pain → parenteral route

- Treatment for opiod withdrawal and dependence → sublingual route

Question 3

Contraindications

Answer 3

• Respiratory depression

- Cardiac arrhythmias

Question 4

pregnancy category?

Answer 4

Pregnancy Category C

Question 5

Adverse Effects

Answer 5

• Respiratory depression

- Prolonged QT interval with long term use of patch form

Question 6

Nursing Considerations

Answer 6

• Protect patch site from heat (may release more)
• Monitor EKG
• May take 1 -2 weeks to become effective