Caffeine

Question 1

Caffeine

Answer 1

CNS + Cardiovascular stimulant, lethal dose 10g, most used

Question 2

Absorption

Answer 2

oral, blood levels significant at 30 min, peak at 2 hours

Question 3

Distribution

Answer 3

whole body, freely crosses brain and placenta

Question 4

Metabolism

Answer 4

Genetics determines the rate

Question 5

Elimination

Answer 5

half life: 2.5-10 hours

Question 6

Mechanism of Action

Answer 6

without caffeine: GABAergic neurons inhibit dopamine release
with caffeine: block adenosine receptors, ^ dopamine release
100-250 mg enhances mental performance, motor activity

Question 7

Short Term Effects

Answer 7

reduces fatigue, constriction of blood vessels, relaxation of bronchial smooth muscle

Question 8

Misuse Potential

Answer 8

Low: mild euphoria

Question 9

SUD Potential

Answer 9

Tolerance: genetics determines
Withdrawal: headache, fatigue
Addiction: mild can occur

Question 10

Therapeutic Effects

Answer 10

stimulate breathing in preterm newborns