Campylobacter

Question 1

Physical description of bacteria

Answer 1

• Gram negative
• curved, helical, gull winged
• polar flagella, sometimes bipolar

Question 2

Type of bacteria

Answer 2

• microaerophile(reduced O2 concentration)

- use growth temperature to differentiate species

Question 3

Temperature and number of bacteria of C. Jejuni

Answer 3

• organism grows at 42C, but not 25C

- infection requires 10^4 orally

Question 4

Organ that is affected most by C. Jejuni

Answer 4

large intestines

Question 5

Clinical presentation of C. Jejuni

Answer 5

• abdominal pain(gastroenteritis)
• cramps, fever, very bloody diarrhea
• may invade bloodstream and cause enteric fever
• self limiting within a week

Question 6

Sequela of C. Jejuni

Answer 6

• 1 to 4 wks after C. Jejuni
• Guillain-Barre syndrome
• autoantibodies to Gm1 gangliosides

Question 7

Epidemiology of C. Jejuni

Answer 7

• zoonosis
• human acquisition via fecal oral route
• consumption of contaminated poultry or milk
• most common in infants and young adults

Question 8

Pathogenesis of C. Jejuni

Answer 8

• produces an inflammatory enterotoxin

- bacteremia indicates an invasive potential

Question 9

Control of C. Jejuni

Answer 9

• rehydration therapy to treat diarrhea

- tetracycline, quinolones, clarithromycin

Question 10

Clinical presentation of C. Fetus

Answer 10

• grows at 25C but not at 42C

- systemic infections, septicemia(rarely diarrhea)

Question 11

Epidemiology of C. Fetus

Answer 11

• zoonosis(naturally in animals, transmission to humans)
• acquire from eating contaminated undercooked beef
• elderly, ill, and immunosuppressed

Question 12

Pathogenesis of C. Fetus

Answer 12

• major virulence factor is an S-layer protein

- S layer protein inhibits complement fixation by C3b; less opsonization so less phagocytosis

Question 13

Control of C. Fetus

Answer 13

-tetracyclines, macrolides, quinolones