CBC

Question 1

Define anemia

Answer 1

Decrease in total amount of red blood cells and hemoglobin in the blood

(decreased ability to carry oxygen)

Question 2

What is the normal RBC count?

Answer 2

• men ~ 4.7 x 10⁶/mL
• women ~ 4.2 x 10⁶/mL

Question 3

When would you see leukocytosis and when would you see leukopenia?

Answer 3

• Leukocytosis during acute infection (11,000/mL)
• Leukopenia during viral infections or overwhelming bacterial infections (<4,000/mL)

(normal range: 4,500-10,500/mL)

Question 4

Which white blood cells are seen during an allergic disorders and or parasitic infection?

Answer 4

Eosinophils and basophils

Question 5

When are monocytes increased?

Answer 5

Severe infection, Phagocytosis

Question 6

What is a “band” (seen in a WBC w/diff.)?

Answer 6

Immature blood cells causing a “left shift”

Question 7

List the white blood cells in order of abundance in the body.

Answer 7

1. Neutrophils
2. Lymphocytes
3. Monocytes
4. Eosinophils
5. Basophils
6. Bands

Question 8

Thrombocytopenia is a low ______

Answer 8

Blood platelet count (<150,000/mL)

(“plt” = platelet)

Question 9

Why is a hemoglobin count monitored?

Answer 9

Anemia dx or to monitor therapy for anemia

Question 10

Hematocrit is a ratio of ______

Answer 10

Packed red blood cells : total volume of whole blood

(men: 36-48%; women: 42-52%)

Question 11

Macrocytic anemia is caused by a(n) ______; whereas microcytic anemia is caused by a(n) ______.

Answer 11

• B12 /folate deficiency
• iron deficiency

(diagnosis of anemia is based on the red blood cell volume & hgb)

Question 12

How is the average red blood cell volume measured?

(dx of anemia)

Answer 12

Mean corpuscular volume (MCV)

(~82-98 fL)

Question 13

What is the main difference between the mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC)?

Answer 13

• MCH: amount of hemoglobin / red blood cell
• MCHC: average hemoglobin concentration / red blood cells volume

Question 14

What is the utility of the MCH and the MCHC?

Answer 14

• MCH: dx severe anemia (26-34 pg/cell)
• MCHC: monitors anemia tx (32-26 g/dL)

Question 15

What does the red blood cell distribution width (RDW) tell us?

Answer 15

Variation of RBC sizes

(~11-14 CV)

Question 16

What is the difference between poikilocytosis and anisocytosis?

Answer 16

• poikilocytosis: variation in size and shape
• anisocytosis: larger than normal variation (either anemia or recently released reticulocytes)

Question 17

Answer 17

Question 18

Answer 18

Thalassemia

Question 19

Answer 19

toxic granulation: inflammatory rxn response of neutrophil (activated)

Question 20

Answer 20

vacuolization: inflammatory monocyte/MF (phagocytosis)

Question 21

Answer 21

atypical lymphocytes (activated; note the blue skirt)

Question 22

Answer 22

Mott cell: ab-producing B cell filled w/ab vacuoles

(neutrophil present to the left)

Question 23

Answer 23

Question 24

Answer 24

Question 25

Answer 25