CEFTRIAXONE

Question 0

PHARMACOLOGY OF CEFTRIAXONE

Answer 0

Cephalosporin antibiotic

Question 1

PRESENTATION OF CEFTRIAXONE

Answer 1

1g sterile powder in a glass vial

Question 2

PRIMARY EMERGENCY INDICATIONS FOR CEFTRIAXONE

Answer 2

• Suspected meningococcal septicaemia

- Severe sepsis ( consult only )

Question 3

CONTRAINDICATIONS OF CEFTRIAXONE

Answer 3

Allergy to Cephalosporin antibiotics

Question 4

PRECAUTIONS FOR CEFTRIAXONE

Answer 4

Allergy to Penicillin antibiotics

Question 5

ROUTE OF ADMINISTRATION OF CEFTRIAXONE

Answer 5

IV (preferred)
IM (if IV access unavailable)

• special notes
• dose dose not exceed 1g
• IV dose made with 10mL sterile water, administered over 2 min
• IM dose made up to 4mL using 1% Lignocaine administered in Lateral upper thigh.

Question 6

SIDE EFFECTS OF CEFTRIAXONE

Answer 6

Nausea
Vomiting
Skin rash

Question 7

ONSET & DURATION OF CEFTRIAXONE

Answer 7

IM/IV
Onset: n/a
Peak: n/a
Duration: n/a

• Note:
• adult 1g dose
• child 50 mg/kg (max 1g)
• IV g + water = 10 mL
• IM g + Lignocaine 1% = 4 mL

Question 8

ADULT DOSAGE OF CEFTRIAXONE

Answer 8

IV
1g + 9.5mL sterile water = 10mL mixture administer slowly over 2min

IM
1g + 3.5mL Lignocaine 1% = 4mL mixture administer Upper lateral thigh or other large muscle mass

Question 9

PAEDIATRIC DOSAGE

Answer 9

IM 50mg/kg + 3.5 mL Lignocaine 1% = 4mL mixture. Administer to upper lateral thigh

*Note: 1g powder max dose regardless of calculation