cell adhesion

Question 1

what are three examples of adhesion molecules, and what type of adhesion do they provide?

Answer 1

classical cadherins (cell-cell)
IG family membres (cell-cell)
integrins (cell-matrix)

Question 2

are classical cadherins homophilic or heterophilic?

Answer 2

homophilic

Question 3

are IG family members homophilic or heterophilic?

Answer 3

both

Question 4

are integrins homophilic or heterophilic?

Answer 4

heterophilic

Question 5

what do cadherins depend on?

Answer 5

calcium ions

Question 6

what does IG stand for?

Answer 6

immunoglobin

Question 7

what do IG family members do?

Answer 7

mediate calcium independent cell-cell adhesion

Question 8

what are types of IG family members?

Answer 8

ICAMs
VCAMs
NCAMs

Question 9

what does ICAM stand for?

Answer 9

intercellular cell adhesion molecules

Question 10

what does VCAM stand for?

Answer 10

vascular cell adhesion molecules

Question 11

what does NCAM stand for?

Answer 11

neural cell adhesion molecule

Question 12

where are VCAMs found?

Answer 12

on blood cells

Question 13

where is NCAM usually found and what does it do?

Answer 13

at adherens junctions
interacts with cadherins to help establish and strengthen specific cell-cell interactions during tissue formation

Question 14

when does an integrin protein switch to its active formation?

Answer 14

when it binds to molecules on either side of the plasma membrane

Question 15

how does integrin change conformation?

Answer 15

has two different subunits (alpha and beta) which switch between a folded inactive form and an extended, active form

Question 16

what does the conformational change on integrin do?

Answer 16

establishes a reversible mechanical linkage across the plasma membrane