Cell cycle checkpoints

Question 1

Checkpoints are activated by?

Answer 1

cell damage, mutation + can delay cell progression to allow DNA to repair

Question 2

Checkpoints are at?

Answer 2

G1, G2 + M phases -restriction point

Question 3

Important restriction point is?

Answer 3

at end of G1 phase, p53 protein

coded by tp53 tumour suppressor gene.

Question 4

If DNA irreparable?

Answer 4

permanent cell arrest and apoptosis

Question 5

Essential components for checkpoints?

Answer 5

ATT, ATM, ChK1, ChK2

Question 6

STOP cell cycle

Answer 6

ATR-ChK1

ATM-ChK2

Question 7

DNA mismatch repair system

Answer 7

recognizing + repairing erroneous insertion,
deletion, + mis-incorporation of bases that can arise during DNA replication +
recombination, as well as repairing some forms of DNA damage