Cell Surface Proteins

Question 1

Helper T cells (Th) markers

Answer 1

CD4, CD40L

Question 2

Cytotoxic T cells

Answer 2

CD8

Question 3

Tregs

Answer 3

CD4, CD25

Question 4

T cells in general

Answer 4

TCR (binds Ag-MHC)
CD3 (assoc with TCR for signal transduction)
CD28 (binds B7 on APC)
CXCR4/CCR5 (HIV)

Question 5

B cells

Answer 5

CD19, 20, 21 (EBV)
CD40
MHC II, B7

Question 6

Macs

Answer 6

CD14/TLR4 (receptor for PAMPs like LPS)
CD40
CCR5
MHC II, B7 (CD80/86)
Fc and C3b (opsonizing like Ab)

Question 7

NK cells

Answer 7

CD56 (unique marker for NK)

CD16

Question 8

Hematopoietic stem cells

Answer 8

CD34

Question 9

What are RBCs lacking in Nocturnal Paroxysmal Hemaglobinuria?

Answer 9

CD55/59

Question 10

B-ALL markers

Answer 10

• TdT
• CD19
• CD10

Question 11

T-ALL markers

Answer 11

• TdT
• Cd2-5
• CD-7
• CD-8
• CD1a sometimes

Question 12

CLL/SLL marker (Mature B-cell leukemia)

Answer 12

• CD19

- CD5 (coexpress T-cell marker)

Question 13

Reed-Sternberg cells are derived from which WBC?

Answer 13

B- cells usually