Vitamins

Question 1

B1 is a cofactor for:

Answer 1

ATP
A = alpha-ketoglutarate dehydrogenase (a-ketoglut to succinyl CoA)
T = transketolase (ribulose-5-P to F-6-P)
P = pyruvate dehydrogenase (pyruvate to acetyl CoA)

Question 2

B2 is related to:

Answer 2

riboFlavin

- FAD, FMN

Question 3

B3 is related to:

Answer 3

Niacin

- NAD+, NADP+

Question 4

B5 is related to:

Answer 4

PENTOthenic acid

• coenzyme A
• fatty acid synthase

Question 5

B6 is related:

Answer 5

PLP

• transamination (ALT/AST)
• decarboxylation
• glycogen phosphorylase
• Synthesis of: cystathione (cystein), heme, niacin, histamine, 5HT, epi, NE, DA, GABA

Question 6

B7 is a cofactor for:

Answer 6

Carboxylation enzymes (to add 1 carbon)

• Pyruvate carboxylase (pyruvate to OAA)
• Acetyl-CoA carboxylase (acetyl-CoA to malonyl CoA)
• Propionyl-CoA carboylase (propionyl-CoA to methylmalonyl CoA)

Note: Avidin in egg whites can lead to biotin def.

Question 7

B9 is a cofactor for:

Answer 7

THF

- For making DNA and RNA bases

Question 8

B12 is a cofactor for:

Answer 8

• methionine synthase

- methylmalonyl-CoA mutase (methylmalonyl-CoA to succinyl-CoA)

Question 9

Vit C is a cofactor for:

Answer 9

Hydroxylation

• Proline and lysine for collagen
• DA B-hydroxylation (DA to NE)