synapses
the point of connection of neurons to other cells
can be divided into two sets of events
pre synaptic and postsynaptic neurons
pre- the sender
post - receiver
the gap between axon terminals
the gap between is called the cleft or synaptic gap
signal mechanism/structure
chemical - neurotrans across synaptic cleft
electrical - ions pass directly through gap
the speed
chemical - several milisecons
electr - instant
signal direction
chem - one way
elec - bidirectional
signal strengths
chem - no loss of signal
elect - diminishes over time
the advantage of chemical vs electrical synapse
the electrical diminishes power over time therefore it may not even reach the threshold or
axodendritic synapse
an axon connected to a dentrite
axoaxonic
axon on another axon
dendrodendritic synapse
between two dendrites
synaptic vesicles
Inside the presynaptic
Contain small molecule neurotransmitters
neurotransmitter granules
vesicles contain large neurotransmitters
5 types of neurotransmitters
small and large
post synaptic -
inhibitory, exitatory
modulating
calcium +2 - presyn
flows into the presynaptic vesicles/granules, tells them to move towards the post-synaptic and release
docking - presyn
process by which synaptic vesicles align themselves to the area where they release the neurotransmitter
exocytosis - exit
endocytosis - enter
process where molecules re exported out of the cell
process where molecules are taken up into a cell
post synaptic events
the receiver will detect and translate the neurotransmitter
changes in the post synaptic membrane
receive, detect , act
ionotrpic receptor
located on the ion channels
they open by changing their shape in response to the binding of neurostrans to its receptor
metabotropic receptor
a shortcut pathway,
the second messenger cascade
g protein-gated ion channel
diffusion
neurotransmitter molecules drift away from the synaptic cleft into extracellular fluid and out of synapse
degradation
specific enzymes from the synaptic cleft chemically break down the neurotrans into inactive
reuptake - transporter curtains
active process where specialized transporter proteins on the presynaptic neuron pump neurotrans from the cleft back into terminal
synaptic integration
process where a neuron combines all the signals it receives to see if it should act on it
whether it reaches the threshold to fire or not