Chronic Tolerance ?
with repeated administration BDZs have less effective ability to modulate GABA
-develops slowly to anticonvulsants
Acute tolerance?varies on the drug being tested and the effect measured
Cross tolerance
seen btwn BZDs and other depressants
-drowsiness produced via doses of BZD is less often in those with recent history of BARBs and Alcohol abuse…
Tolerance to BZDs and BARBs could be
similar in mechanisms…