What is evolution?
The gradual changes in the characteristics of a species over many generations, resulting from changes in allele frequencies in a population’s gene pool
Define gene pool
The sum of all alleles in given population at a particular time
What are allele frequencies?
The proportion of each allele of a gene present in a population’s gene pool
Name the two types of mutations
Gene mutation: Affects a single gene
Chromosomal mutation: Affects part or whole chromosomes
What are mutagens? Give examples
Agents that increase the rate of mutations
e.g. mustard gas, UV light, x-rays
Difference between somatic and germline mutations?
Somatic mutations occur in body cells and affect only the individual
Germline mutations occur in reproductive cells and can be inherited
What is a point mutation?
A mutation involving the change of a single nucleotide (insertion, deletion or substitution)
What is a frameshift mutation?
A mutation where bases are added or removed, shifting the reading frame of codons and altering all amino acids from that point
Give two examples of conditions caused by gene mutations
-Duchenne muscular trophy
-Cystic fibrosis
Give two examples of conditions caused by chromosomal mutations
-Down syndrome (trisomy 21)
-Turner syndrome (monosomy X)
What is gene flow?
The movement of alleles from one population to another due to migration
Give two types of barriers to gene flow
-Geographical (mountains, oceans, rivers)
-Sociocultural (religion, language)
List the principles of natural selection
-Variation
-Overpopulation
-Competition
-Heritability
-Allele frequency
What is a selective agent?
An environmental factor that influences which individuals survive and reproduce
Define heterozygote advantage and give an example
-When a heterozygous individuals have a survival benefit over both homozygotes. Example: Sickle cell
What is genetic drift?
A random, non-directional change in allele frequencies between generations
What is the founder effect?
When a new population is established by a small group, leading to reduced genetic variation and different allele frequencies from the original frequencies
What is the bottleneck effect?
A severe reduction in population size due to chance events, causing changes in allele frequencies
Define speciation
The formation of new species due to reproductive isolation and genetic divergence
What are the steps in speciation?
-Variation: There is variation between individuals of a species
-Isolation: Populations of the same species are isolated without gene flow
-Selection: Each population is subjected to different selective agents
-Speciation: The allele frequency changes until they become so different that the two groups are no longer able to interbreed