Cholesterol

Question 1

• Anticoagulants prevent

Answer 1

o Complications of atrial fibrillation
o Pumonary embolism
o Myocardia infarction
o Ischemic stroke

Question 2

o Apsrin

Answer 2

 Inhibits COX1 irreversibly
 COX 1 enzyme involved in synthesis of platelets thromboxane A2
 Adver effect: bleeding

Question 3

o Clopidrogrel

Answer 3

 Inhibits ADP blinding to platelet P2Y recepros leading to inhibitiosn of platelet activation
 Oral active
 Converted to active metabolite by CYP 450
 Adverse effect: bleeding
 Prevents ischemic stoks and heart attacks

Question 4

Heparin

Answer 4

 Administration parenteral (intravenous, and subcutaneous) does not cross membranes
 Blinds to and activates antithrombin increases antithrombin activity
 Used to treat acute deep bein thrombosis and pulmonary embolism
 Used as preventative after myocardil infraction

Question 5

o Warfarin

Answer 5

 Mehcanims of action: Virtamin K
* Inhibits re activation of vitamin K
* Orally active
 Narrow therapeutic index
 Adverse effect: Bleeding – reversed by vitamin K infusion
 Warfain reversal: stop warfarin, vitamin K, fresh frozen plasma, prothrombin complex conenctrate