Vasodilator unit

Question 1

Nitroglycerin

Answer 1

o Converted to the active metabolit, nitric oxide in vascular smooth muscle
o Treatment for acute anginal attack
o Long lasting formular
 Tansdermal patch
 Ointment
 Tablets
 Relatively fast
Nitrovasoldialtors

Question 2

Isosorbid dinitrate and isosiorbid 5 mononitrate

Answer 2

o Most commonly oral
o Ultimately produce nitric oxide
o Tolerance is a problem
- Side effects
o Head aches common
o Withdrawl anginal robound
o Tolerance
o hypotension
nitrovasodilators

Question 3

Nifedipine

Answer 3

o Id a dihydropyridine with greater vascular selectivity than other classes of calcium blockers
o Treatment for angina and hypertension
o Not uses as an antiarrythmic since less of an effect on cardiac calcium
Calcium blocker

Question 4

Diltaizem

Answer 4

o Similar potency on vascular and cardiac muscle
o Clinical: angina, hypertension and arrhythmias
calcium blocker

Question 5

Verapamil

Answer 5

o Similar potency on vascular and cardiac muscle
o Clinical: angina, hypertension, and arrhythmias
- Adverse effects:
o PExcessive vasodilation:
 Peripheral edema
 Hypotension
 Headache, dissiness, flushing, nausea
o Excessive cardiac smooth muscle depression
 Bradycardia
 AV block
 Congestive heart failure
calcium blocker

Question 6

Ranolzaine

Answer 6

o Inihits a sosium current in cardiac muscle cells decreases sodum concentration
 Promotes calcium outflow from the cells
o Decreases calcium concentration decreases cardiac muscle contractility and oxygen demand
o No significant effects on HR and BP
o Does not cross the BBB

sodium channel blockers