Cholesterol

Question 1

how are lipids transported

Answer 1

2% (mostly FA) carried bound noncovalently to albumin but theres a limited capacity of 3mmol/L

98% of lipids are carried bound noncovalently to lipoprotein particles consiting of cholesterol, cholesterol esters, proteins, TAG

Question 2

total serum cholesterol?

Answer 2

<5mmol/L

Question 3

what are plasma lipoproteins

Answer 3

• complex that contain different lipids (cholesterol, cholesterol esters, TAG, phospholipids)
• membranes are phospholipid monolayer with small amounts of cholesterol
• associated with specific apolipoproteins ; which are intergral or peripheral.
  
  • peripheral: apoC (binds to LPL on adipocytes and muscle) apoE (binds to LDL receptor on hepatocytes)
  • intergral: apoA and apoB (apoB-48 added before entering lymphatic/apoB-100 added during fromationof apoC and apoE)