collagen and elastin things

Question 1

steps of collagen synthesis (think of the alphabet backwards)

Answer 1

1= Synthesize it–> gly-x-y
2= Hydroxylate it–> req vit C
3= Glycosylate it –> form procollagen tripple helix
^^^^^^ occur in RER

4= Exocytosis it --> procollagen to extracell space
5= Cleave it (proteolytic processing) --> cleave n and c terminals to make insoluble tropocollagen
6= Cross link

S-H-G-E-C-C

Question 2

ehlers danlos and menkes diseases are problems with ________ step of collagen synth

Answer 2

cross linking

Question 3

scurvy is a problem with ______ step in collagen synth

Answer 3

hydroxylation (second step after synthesis) requies Vit C

Question 4

osteogenesis imperfecta is a problem with _____ step of collagen synth

Answer 4

glycosylation –> can’t form triple helix

Question 5

what enzyme stabilizes cross linked collagen fiber

Answer 5

lysl oxidase