renal

Question 1

PSGN- bx (nephritic)

Answer 1

IF- C3 staining on GBM

EM- subepi humps –> these are self limiting and will slowly progress out of the capillary

Question 2

anti-gbm (nephritic)

Answer 2

• ab against type IV collagen
• LM= CRESCENTS
• IF= LINEAR

Question 3

RPGN (nephritic)

Answer 3

• cresents

- lm= fibrinogen

Question 4

what are “crescents” composed of? what path processes are they seen in?

Answer 4

fibring+ macrophages

-goodpastures, rpgn

Question 5

IgA nephropathy (nephritic)

Answer 5

• young adults

- IgA in mesangium due to increased IgA in response to mucosal infx

Question 6

alport syndrome (nephritic)

Answer 6

defective Type IV collagen –>

EM= lamellate appearance of GBM