bernard soulier
low GpIb –> vwf-plt
glanzmann thrombasthenia
low GpIIb/IIIa –> plt-plt
no clumping on smear
hemolytic uremic syndrome
thrombocytopenia, microangiopathi memmolytic aemia, acute reanal fialure
tx: plasmapheresis
immune thrombocytopenia
ANTI-gpbII/IIIa –> splenic consumption
smear: increase megas
tx: IVIG, splenectomy, steroids
thrombotic thromocytopenic purpura
problem with ADAMTS13 –> can’t cleave vWF multimers
thrombosis
labs: schistocytes, increase LDH
dx= fever, malaise, microangiopathic hemolytic anemia, thrombocyto
tx= plasmapheresis