Complement and interferon - Final

Question 1

Where are the proteins of the complement system made?

Answer 1

-Liver
-Macrophages

Question 2

Which immune system is the complement system a part of?

Answer 2

Innate immune system

Question 3

What are the 4 functions of complement?

Answer 3

1. Opsonization
2. Chemotaxis
3. Cell lysis
4. Inflammation

Question 4

Tagging pathogens for phagocytosis

Answer 4

opsonization

Question 5

Attracting immune cells to infection site

Answer 5

Chemotaxis

Question 6

Destroying pathogens via membrane attack complex (MAC)

Answer 6

Cell lysis

Question 7

Promoting immune cell activation

Answer 7

Inflammation

Question 8

What are the 3 complement activation pathways?

Answer 8

1. Classical pathway
2. Lectin pathway
3. Alternative pathway

Question 9

What do interferons respond to?

Answer 9

Viral infections and other immune triggers

Question 10

What do interferons help regulate?

Answer 10

Immune responses

Question 11

What immune system in interferon a part of?

Answer 11

Innate immunity

Question 12

What are interferons produced by?

Answer 12

-Dendritic cells
-Fibroblasts
-Indirectly with PRRs

Question 13

What are the 3 types of interferons?

Answer 13

Type I
Type II
Type III

Question 14

antiviral response, activates NK cells

Answer 14

Type I interferons

Question 15

Activates macrophages, enhances antigen presentation

Answer 15

Type II interferons

Question 16

Acts mainly on epithelial cells, had antiviral effects

Answer 16

Type III interferons

Question 17

How long does interferon production take?

Answer 17

Immediate, minutes

Question 18

What do interferons act on?

Answer 18

Locally on infected & non-infected cells

Question 19

What is apoptosis?

Answer 19

Programmed cell death

Question 20

What are the key players in innate immunity?

Answer 20

Complement & interferon

Question 21

Protein cascade that enhances immune defense

Answer 21

Complement

Question 22

What 2 things do complement stimulate

Answer 22

1. Inflammation
2. Phagocytosis

Question 23

Signaling proteins that regulate & amplify immune responses. They are released by host cells in response to pathogens, especially viruses. They help coordinate the immune response & protect neighboring cells.

Answer 23

Interferons

Question 24

What 2 things are interferons used for?

Answer 24

Viral defense
Therapy

Question 25

A group of proteins in the blood & tissues that help the immune system fight infections

Answer 25

Complement system

Question 26

3 things interferons are crucial for

Answer 26

1. Antiviral defense 2. Immune regulation 3. Communication between immune cells

Question 27

Triggered by antibodies

Answer 27

Classical pathway

Question 28

Triggered by lectin binding to pathogen

Answer 28

Lectin pathway

Question 29

Triggered directly by pathogen surfaces

Answer 29

Alternative pathway