Complement System

Question 1

C1 Complex

Answer 1

C1q + C1r + C1s | CLASSICAL PATHWAY

Mechanism: https://prnt.sc/aBHvLUFE2wKI

Question 2

C3 Convertase Classical Pathway

Answer 2

C3 Convertaste:

C3 > C3a (Inflammation) + C3b (Opsonin)

C3b + C3 Convetaste = C5 Convertaste

Question 3

C5 Convertase Classical Pathway

Answer 3

C5 Convertaste

C5 > (+) MAC Formation

Question 4

Each complement protein function

Answer 4

C3a + C4a+ C5a > Inflammation
C3b > Opsonization
C5b to C9 > MAC

Question 5

Membrane Attack Complex Formation & Mechanism

Answer 5

IMG

Question 6

Complement Control Proteins

Answer 6

Properdin (+ Alt. pw)
Factor H (- Alt. pw)

DAF (Decay-accelerating factor)
MCP (Membrane cofactor protein)
Both C3 Convertase Inhibitors

Question 7

Other C3 Convertaste Inhibitors

Answer 7

C4BP + Factor I > Inhibit C3 Convertase

Question 8

Function of CD59

Answer 8

CD59 > Inhibit MAC; by binding to C5b678 (no C9 recruitment)

Question 9

Associated diseases with C1 protein deficiency

Answer 9

Systemic lupus erythematosus, pyogenic infections

Question 10

Associated diseases with C4 protein deficiency

Answer 10

Systemic lupus erythematosus, glomerulonephritis

Question 11

Associated diseases with C2 protein deficiency

Answer 11

Systemic lupus erythematosus, vasculitis, glomerulonephritis, pyogenic infections

Question 12

Associated diseases with C3 protein deficiency

Answer 12

Pyogenic infections, glomerulonephritis, immune complex disease

Question 13

Associated diseases with C9 protein deficiency

Answer 13

None

Question 14

Associated diseases with C1 inhibitor protein deficiency

Answer 14

Hereditary angioneurotic edema

Question 15

Associated diseases with DAF & CD59 protein deficiency

Answer 15

Paroxysmal nocturnal hemoglobinuria