Effector Th-Cells

Question 1

Th1

Answer 1

IL-12, IFN-γ, TNF-α
↓
STAT 1 & STAT 4
↓
T-bet
↓
Effector function:
1. M1 macrophage activation
2. Enhancement of MHC-associated antigen presentation
3. Help in the prod. of cytotoxic T-cells
4. Establishment of antiviral state

Question 2

Th2

Answer 2

IL-4
↓
STAT-6
↓
GATA-3
↓
(+) IgE
(+) Mast Cell
(+) Eosinophil

Serve to eradicate helminthic infections

Question 3

Th17

Answer 3

IL-23, IL-6, IL-1, TGF-β
↓
STAT-3
↓
RORγt
↓
Th17

(+) IL-17
(+) IL-22

Induces neutrophilic inflammation

Question 4

Tfh

Answer 4

CXCR5, ICOS
↓
BCL-6
↓
Tfh

(+) IL-21

Helps B-cells make quality antibodies