T-Cell Development

Question 1

cTEC function

Answer 1

1. Attract hematopoietic precursors
2. T-cell commitment
3. Initiate immature T-cell expansion
4. POSITIVE selection
5. NEGATIVE selection

Question 2

mTEC function

Answer 2

1. NEGATIVE selection
2. Maturation signals to +/- selected thymocytes
3. Niche for regulatory T-cell dev.