corticosteroids

Question 1

corticosteroids group

Answer 1

glucocorticoids

Question 2

corticosteroids moa

Answer 2

• inhibits phospholipase A2
• vasoconstriction
• antiproliferative
• anti inflammatory
• immunosuppressive action

Question 3

corticosteroids uses

Answer 3

1. replacement therapy- acute adrenal insufficiency, addison’s disease
2. rheumatoid arthritis, osteoarthritis, rheumatic fever
3. SLE,PAN, nephrotic syndrome, Glomerulonephritis
4. severe allergic reaction
5. autoimmune disease such as hemolytic anemia, ITP
6. bronchial asthma
7. ulcerative colitis, crohn’s disease, celiac disease
8. malignancy such as leukemia, Hodgkin’s lymphoma

Question 4

corticosteroids A/E

Answer 4

1. cushing’s habitus- round face, narrow mouth, hump, obesity
2. fragile skin, purple striae, bruising, hirsutism
3. hyperglycemia
4. myopathy
5. susceptibility to infection
6. delayed healing of wounds
7. osteoporosis
8. growth retardation
9. fetal abnormalities

Question 5

corticosteroids classification

Answer 5

1. hydrocortisone(short acting t1/2<12 hrs)
2. prednisolone (intermediate t1/2 12-36 hrs)
3. dexamethasone (long acting t1/2 >36hrs)