physostigmine

Question 1

physostigmine group

Answer 1

anticholinesterase

Question 2

physostigmine moa

Answer 2

a) muscarinic action
- heart=bradycardia
- blood vessels= vasodilation
- smooth muscle= contraction
- tone and peristalsis in git increases, sphincter relaxation
- bronchial muscle= contraction
- glands =secretion
- eyes= miosis

b) nicotinic action
- skeletal muscle= contraction

c)cns action= excitation followed by depression

Question 3

physostigmine uses

Answer 3

• as miotic:
  1. glaucoma
  2. to reverse effect of mydriasis after refraction testing
• myasthenia gravis
• postop paralytic ileus/ urinary retention
• cobra bite
• alzheimers disease

Question 4

physostigmine A/E

Answer 4

• diarrhea
• increased urination
• miosis
• bradycardia, bronchospasm
• emesis
• lacrimation
• salivation
• sweating