AUBF > CSF > Flashcards

CSF Flashcards

(85 cards)

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1
Q

Cerebrospinal fluid is primarily used to evaluate the

A

Central nervous system

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2
Q

CSF function (3)

A

Supply nutrients

Remove metabolic waste

Produce mechanical barrier to cushion the brain

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3
Q

brain and spinal cord are lined with

A

Meninges

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4
Q

Lines the skull and vertebral canal

A

Dura mater

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5
Q

Described as filamentous and spider like

A

Arachnoid

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6
Q

Thin membrane lining the surfaces of the brain and spinal cord

A

Pia mater

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7
Q

CSF is produced in the

A

Choroid plexus

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8
Q

CSF flows through the

A

Subarachnoid space

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9
Q

Normal CSF production in adults per hour is approximately

A

20 mL

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10
Q

CSF is reabsorbed into the blood through

A

Arachnoid granulations or villae

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11
Q

Tight fitting structure of the endothelial cells in the choroid plexus is termed the

A

Blood brain barrier

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12
Q

The procedure used to obtain CSF is

A

Lumbar puncture

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13
Q

A contraindication for lumbar puncture is

A

Infection at the puncture site

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14
Q

CSF is usually collected in

A

Three or four sterile tubes

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15
Q

Volume of CSF

A

10 to 20 mL

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16
Q

If only one tube is collected, it should be used for

A

Microbiology

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17
Q

Tube #1 is mainly used for

A

Chemical and serologic tests

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18
Q

Test are least affected by blood or bacteria introduced as a result of the tap procedure

A

Tube #1

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19
Q

Preservation of tube #1

A

Frozen

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20
Q

Tube #2 it’s mainly used for

A

Microbiology laboratory

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21
Q

Preservation of tube #2

A

Remain at room temperature

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22
Q

Tube #3 it’s mainly used for

A

Cell count

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23
Q

Preservation of tube #3

A

Refrigerated

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24
Q

Least likely to contain cells introduced by the spinal tap procedure

A

Tube #3

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25
Provide better exclusion of skin contamination
Tube #4
26
Tube #4 is mainly used for
Microbiology and additional serologic test
27
Normal CSF appearance is
Crystal clear
28
Hazy, turbid, milky, cloudy CSF may indicate
WBCs, microorganisms and proteins
29
Bloody CSF may indicate
Hemorrhage and traumatic tap
30
Clotted CSF may indicate
Protein and clotting factors
31
Xanthochromic is commonly caused by
Hemoglobin Bilirubin Carotene protein melanin Old hemorrhage Melanosarcoma
32
Pellicle formation is associated with
Protein and clotting factors
33
Uneven blood distribution in tube
Traumatic tap
34
Even blood distribution
Intracranial hemorrhage
35
Not enough fibrinogen to clot
Intracranial hemorrhage
36
Clear supernatant in xanthochromic
Traumatic tap
37
RBC hemolysis after two hours
Intracranial hemorrhage
38
Back up test of xanthochromic in intracranial hemorrhages
D-dimer test & microscopic finding of erythrophagocytosis
39
All you went should be checked ______ for contamination
Weekly
40
Speed of the cytocentrifuge should be checked_____ With tachometer
Monthly
41
If nondisposable counting chambers are used, they must be soak in a bactericidal solution for at least _____
15 minutes
42
Normal WBC count in CSF is
0-5/uL
43
Specimens that contain up to______or______ may appear clear
200 WBCs or 400 RBCs/uL
44
3% glacial acetic acid is used to
Lyse RBC
45
Methylene blue is used to
Differentiate neutrophils and mononuclear cells
46
Differential count is performed using
Wright stain
47
Cytocentrifuge or routine centrifuge differential count for
5 to 10 minutes
48
100 cells report in: <100 report in:
Percentage Only the numbers of cell types seen
49
Lymphocytes in CSF commonly indicate
Viral Tubercular Fungal meningitis Multiple sclerosis
50
Neutrophils in CSF commonly indicate
Bacterial meningitis Cerebral hemorrhage
51
RBCs in spinal fluid contrast media
Macrophages
52
Blast forms in CSF indicate
Acute leukemia
53
Plasma cells are associated with
Multiple sclerosis
54
Non-pathologically significant cells (3)
Choroidal cells Ependymal cells Spindle shaped cells
55
Normal CSF protein in adults is
15 to 45 mg/dL
56
Normal CSF in infants is
150 mg/dL
57
Normal CSF in immature is
500 mg/dL
58
Increase CSF routine indicate (2)
Damage to BBB Production of Igs in CNS
59
Decreased CSF protein indicates
CSF leakage
60
Major CSF protein is
Albumin
61
2nd most major CSF protein is
Prealbumin
62
Haptoglobin and ceruloplasmin
a-globulin
63
B-transferrin and carbohydrate deficient transferrin “tau” Found in CSF, but not in serum
Beta-globulin
64
IgG and IgA Not found in CSF are IgM, fibrinogen,and lipids
Gamma-globulin
65
CSF protein is normally
15 to 45 mg/dL
66
Less than 9 represents an intact blood brain barrier
CSF/serum albumin index
67
Assessment of conditions with IgG production within CNS
IgG index
68
Protein component of lipid protein complex that insulates the nerve fibers
Myelin basic protein
69
CSF glucose is normally
60 to 70% of plasma
70
Lactate is >25
Fungal meningitis
71
Lactate >35
Bacterial meningitis
72
Lactate <25
Viral meningitis
73
Glutamine is normally
8 to 18 mg/dL
74
Frequently requested procedure for patients with coma of unknown origin
Glutamine
75
24 hour
Bacterial
76
6 weeks
Tubercular
77
India ink preparation is used to detect
Cryptococcus neoformans
78
Birth to one month
S. agalactiae
79
One month to five years old
H. influenza
80
5 to 29 years old
N. meningitides
81
Greater than 29 years old
S. pneumonia
82
Infants, elderly, and immunocompromised
L. monocytogenes
83
Test for neurosyphilis
Venereal disease research laboratories (VDRL)
84
Test for syphilis
Fluorescent Treponemal antibody absorption (FTA-ABS)
85
Test is not recommended because it is less sensitive than VDRL
Rapid plasma regain (RPR)
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