Digoxin

Question 1

Mech of action?

Answer 1

Negatively chronotropic and positively inotropic
Decreases heart rate, increases contractility
Increases vagal tone
Less conduction at the AV node, slowing down ventricular rate.
In HF, it inhibits the Na/K ATP ase so sodium accumulates inside cells, so Ca does too-more contractile force

Question 2

I?

Answer 2

AF, atrial flutter to reduce ventricular rate

severe HF-third line or earlier of existing AF

Question 3

C?

Answer 3

arrhythmias, renal failure, hypokalaemia, hypomagnesia, hypercalcaemia, loop and thiazides, amiodarone, CCB spironolactone and guinine

Question 4

A?

Answer 4

bradycardia, GI, rash, dizziness, visual disturbances, arrhythmias, digoxin toxicity