warfarin

Question 1

M?

Answer 1

Inhibits hepatic production of vitK-dependent coagulation factors and cofactors
Inhibits VitK epoxide reductase, which reactivates vitK once oxidised so coagulation factors cannot be made.

Question 2

I?

Answer 2

prevents clot extension and recurrence in DVT or PE

prevents complications in AF/heart valve replacement

Question 3

C?

Answer 3

risk of haemorrhage, liver disease, trauma, pregnancy,ccp450 inhibitors/inducers, antibiotics

Question 4

A?

Answer 4

bleeding
epistaxis
retroperitoneal haemorrhage