DMD - L3

Question 1

Topics?

Answer 1

DMD
   statistics
   clinical presentations
   diagnosis
   disease progression
   complications
BMD
   statistics
   disease progression

Question 2

DMD statistics?

Answer 2

onset

Question 3

DMD clinical presentations? (7)

Answer 3

delayed motor milestones (walking >18 months)
gait difficulties (proximal, Gower’s manoeuvre)
enlarged, rubbery muscles
weak neck flexors
lumbar lordosis
fatigability
speech delay, learning problems

Question 4

DMD diagnosis?

Answer 4

serum creatine kinase (normal

Question 5

DMD disease progression?

Answer 5

3-6 years
8 years
10-13 years
teen-early 20s

Question 6

DMD complications? (6) Explain each one

Answer 6

respiratory deficit
sleep-disordered breathing
cardiac involvement
orthopaedic involvement
CNS involvement
cognitive issues

Question 7

BMD statistics?

Answer 7

onset >5 years
incidence 1/35,000 male births
clinical onset variable
wheelchair dependency >16yrs

Question 8

BMD disease progression?

Answer 8

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