Molecule to Malady > RA - L4 > Flashcards

RA - L4 Flashcards

(6 cards)

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1
Q

Patterns of Bone Loss in RA

A

juxta-articular osteopenia
focal bone erosion
systemic osteoporosis

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2
Q

Where does RANKL come from?

A 
osteoblasts
synovial fibroblasts (additional source)
T cells (additional source)
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3
Q

What are the cells responsible for bone erosion in RA?

A

osteoclasts ONLY

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4
Q

What is OPG.Fc treatment?

A

increase in OPG expression

decreased bone erosion

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5
Q

What cytokines promotes osteoclast differentiation directly?

A

RANKL
IL-1
TNF

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6
Q

What cytokines promotes osteoclast differentiation indirectly?

A

TNF
IL-6
IL-1
IL-17

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