Dopamine Pathways

Question 1

Which dopamine pathway is associated with positive psychotic symptoms?

Answer 1

Mesolimbic pathway

Question 2

Hyperactivity of dopamine in which pathway causes hallucinations and delusions?

Answer 2

Mesolimbic pathway

Question 3

Blocking D2 receptors in which pathway treats positive symptoms of schizophrenia?

Answer 3

Mesolimbic pathway

Question 4

Which dopamine pathway is associated with negative symptoms such as apathy and emotional withdrawal?

Answer 4

Mesocortical pathway

Question 5

Decreased dopamine in which pathway contributes to negative and depressive symptoms of schizophrenia?

Answer 5

Mesocortical pathway

Question 6

Which dopamine pathway regulates motor movement?

Answer 6

Nigrostriatal pathway

Question 7

Dopamine blockade in which pathway leads to extrapyramidal symptoms (EPS)?

Answer 7

Nigrostriatal pathway

Question 8

Parkinson’s disease primarily affects which dopamine pathway?

Answer 8

Nigrostriatal pathway

Question 9

Long-term D2 blockade causing tardive dyskinesia involves which pathway?

Answer 9

Nigrostriatal pathway

Question 10

Which dopamine pathway regulates prolactin secretion?

Answer 10

Tuberoinfundibular pathway

Question 11

D2 blockade in which pathway leads to increased prolactin levels?

Answer 11

Tuberoinfundibular pathway

Question 12

Amenorrhea, galactorrhea, and sexual dysfunction are linked to dysfunction of which pathway?

Answer 12

Tuberoinfundibular pathway due to higher prolactin levels

Question 13

What is a key distinguishing feature of atypical antipsychotics?

Answer 13

5HT2A (serotonin) receptor antagonism

Question 14

Typical antipsychotics primarily block which receptor?

Answer 14

Dopamine D2 receptor

Question 15

Increased acetylcholine due to dopamine blockade occurs in which pathway?

Answer 15

Nigrostriatal pathway