Schizophrenia

Question 1

Enlarged ventricles
Smaller frontal and temporal lobes
Reduced symmetry in temporal and occipital lobes
Decreased cerebral flow
Hippocampus and amygdala reduction

These are all brain changes in what condition?

Answer 1

Schizophrenia

Question 2

Neurotransmitter involvement with schizophrenia

Answer 2

Excess dopamine
Excess glutamate
Decreased GABA
Decreased serotonin

Question 3

Age of onset for schizophrenia in males?

Answer 3

18-25

Question 4

Age of onset for schizophrenia in females?

Answer 4

25-35

Question 5

What are the positive symptoms of schizophrenia?

Answer 5

hallucinations, delusion, referential thinking, hostility, grandiose, mania, suspiciousness

Question 6

What are the negative symptoms of schizophrenia?

Answer 6

Flat affect, alogia, avolition, apathy, abstract thinking, anhedonia, attention defecit

Question 7

What is the etiology of schizophrenia?

Answer 7

Inadequate synapse formation
Excessive pruning of synapse
Excitotoxic death of neurons
Intrauterine insults (oxygen deprivation, prenatal exposure to toxins, maternal malnutrition)

Question 8

What is alogia?

Answer 8

poverty of speech

Question 9

What is Avolition?

Answer 9

lack of motivation or ability to do tasks

Question 10

Which antipsychotics are the least sedating?

Answer 10

Ziprasidone (Geodon), lurasidone (Latuda), and aripiprazole (Abilify)

Question 11

What is the role of ACT in management of schizophrenia?

Answer 11

Assertive Community Treatment is a program that prepares patients to live within the community and ensures placement of mentally ill with supportive services

Question 12

What is typically the first sign of metabolic syndrome?

Answer 12

Increased waist-to-hip ratio

Question 13

Is ACT only for schizophrenia?

Answer 13

No - it can be used for any mentally ill individual that is non-compliant and requires frequent hospitalizations to try and minimize admissions

Question 14

Before prescribing any antipsychotics, what needs to be completed?

Answer 14

Routine labs: serum glucose, lipid panels, weight, BMI, measure waist-to-hip ration, liver and kidney function, CBC

Question 15

What needs to be conducted annually on patients taking seroquel or other typical antipsychotics?

Answer 15

Eye exam - due to risk of cataract development

Question 16

First action when a patient develops weight gain/metabolic syndrome on antipsychotics?

Answer 16

Encourage an increase of physical activity