1
Q
Furosamide:
- Type of drug?
- M of A?
- Treat?
- Adverse?
- Electro effects?
A
- Loop diuretic
- Act on thick ascending limb to block NaCl cotransporter
- HF, volume overload
- Hypokalemia, metabolic alkalosis; hyperuricemia
- Increase uric, decrease K, H, Ca, Mg
- Efficacious*
2
Q
HCT:
- Type of drug?
- M of A?
- Treat?
- Adverse?
- Electro effects?
A
- Thiazide diuretic
- Distal conv. tubule inhibits NaCl co-trans
- HF, volume overload; supplement loop
- hypokalemia
- Small decrease in K and H; big increase in Ca and uric
3
Q
Spironalactone:
- Type of drug?
- M of A?
- Treat?
- Adverse?
- Electro effects?
A
- Potassium sparing diuretic
- Collecting tubule; aldo receptor antag on heart
- HF, anti remodelling, RAAS antag
- Hyperkalemia; gynocamastia
- More potassium
4
Q
Epleronone:
- Type of drug?
- M of A?
- Treat?
- Adverse?
- Electro effects?
A
- Potassium sparing diuretic
- Collecting tubule; aldo receptor antag on heart
- HF, anti remodelling, RAAS antag
- Hyperkalemia
- More potassium
5
Q
Lisinopril:
- Type of drug?
- M of A?
- Treat?
- Adverse?
- Electro effects?
A
- ACE vasodilator
- Inhibit Ang1 –> Ang 2
- HF, inhibit vasoconstriction, less Bradykinin breakdown, anti remodelling, inhibit aldosterone
- Cough, hyperkalemia
- Increase K+
6
Q
Captopril:
- Type of drug?
- M of A?
- Treat?
- Adverse?
- Electro effects?
A
- ACE vasodilator
- Inhibit Ang1 –> Ang 2
- HF, inhibit vasoconstriction, less Bradykinin breakdown, anti remodelling, inhibit aldosterone
- Cough, hyperkalemia
- Increase K+
7
Q
Enalopril:
- Type of drug?
- M of A?
- Treat?
- Adverse?
- Electro effects?
A
- ACE vasodilator
- Inhibit Ang1 –> Ang 2
- HF, inhibit vasoconstriction, less Bradykinin breakdown, anti remodelling, inhibit aldosterone
- Cough, hyperkalemia
- Increase K+
8
Q
Valsartan:
- Type of drug?
- M of A?
- Treat?
- Adverse?
- Electro effects?
A
- ARB vasodilator
- ANG2 receptor antagonist
- HF, anti remodelling, inhibit vasoconstriction, inhibit aldo
- Slow on/off, high half life, many DDI’s
- Increase K+
9
Q
Losartan:
- Type of drug?
- M of A?
- Treat?
- Adverse?
- Electro effects?
A
- ARB vasodilator
- ANG2 receptor antagonist
- HF, anti remodelling, inhibit vasoconstriction, inhibit aldo
- Slow on/off, high half life, many DDI’s
- Increase K+
10
Q
Candasartan:
- Type of drug?
- M of A?
- Treat?
- Adverse?
- Electro effects?
A
- ARB vasodilator
- ANG2 receptor antagonist
- HF, anti remodelling, inhibit vasoconstriction, inhibit aldo
- Slow on/off, high half life, many DDI’s
- Increase K+
11
Q
Propranolol:
- Type of drug?
- M of A?
- Treat?
A
- BB
- Not approved for HF
12
Q
Metroprolol:
- Type of drug?
- M of A?
- Treat?
A
- BB
- B2 antagonist
- anti remodeling, reduces HR to improve EF
13
Q
Carvedilol:
- Type of drug?
- M of A?
- Treat?
A
- BB
- a1, B1, B2 antagonist
- anti remodeling, reduces HR to improve EF
- Gold Standard*
14
Q
Digoxin:
- Type of drug?
- M of A?
- Treat?
A
- Inotrope/ cardiac glycoside
- Na+/K+ ATP-ase antagonist; increases in IC Na+ leads to increase IC calcium
- Improves CO, EF, and pump function
15
Q
Milranone:
- Type of drug?
- M of A?
- Treat?
A
- Inotrope/ PDEI
- Prevent breakdown of cAMP by PDE
- HF
16
Q
Dobutamine:
- Type of drug?
- M of A?
- Treat?
A
- Inotrope/ Beta adrenergic agonist
- Potent B1 agonist
- CHF
- Less B receptor down regulation*
17
Q
Epinephrine:
- Type of drug?
- M of A?
- Treat?
A
- Inotrope/ Beta adrenergic agonist
- a and B receptors
- CHF, cardiopulmonary bypass
18
Q
Norepinephrin:
- Type of drug?
- M of A?
- Treat?
A
- Inotrope/ Beta adrenergic agonist
- Less potent than epi at B2; potent a1 agonist (vasoconstrictor)
- HF
19
Q
Dopamine
- Type of drug?
- M of A?
- Treat?
A
- Inotrope/ Beta adrenergic agonist
- Increase and decrease NE
- Low dose vasodilator/ high dose vasoconstrictor
20
Q
Procainamide:
- Type of drug?
- M of A?
- Effect on phase 2? Conduction rate? Refractory period? Upstroke?
- Misc?
A
- Class 1a anti arrhythmic
- Na channel blocker
- Prolongs phase 2; slower; longer; slower
- Fast AP’s
21
Q
Flecaininide:
- Type of drug?
- M of A?
- Effect on phase 2? Conduction rate? Refractory period? Upstroke?
- Misc?
A
- Class 1c anti arrhythmic
- Na channel blocker
- pronounced slowing upstroke; mildly longer depolorization
- Fast AP’s
22
Q
Lidocaine:
- Type of drug?
- M of A?
- Effect on phase 2? Conduction rate? Refractory period? Upstroke?
- Misc?
A
- Class 1b anti arrhythmic
- Na channel blocker
- slow upstroke; mildly shorter depolarization, prolonged phase 4
- Fast AP’s
23
Q
Propranolol:
- Type of drug?
- M of A?
- Effect on phase 2? Conduction rate? Refractory period? Upstroke?
- Misc?
A
- Class 2 anti arrhythmic
- B-AR
- Increased refractory period
- Reduces pacing
- SLow AP’s
24
Q
Amiodarone:
- Type of drug?
- M of A?
- Effect on phase 2? Conduction rate? Refractory period? Upstroke?
- Misc?
A
- Class 3 anti arrhythmic
- K+ channel blocker
- prolongs phase 2; lengthens refractory period
- Fast AP’s
25
Ibutillide:
- Type of drug?
- M of A?
- Effect on phase 2? Conduction rate? Refractory period? Upstroke?
- Misc?
- Class 3 anti arrhythmic
- K+ channel blocker
- prolongs phase 2; lengthens refractory period
- Fast AP's
26
Verapimil:
- Type of drug?
- M of A?
- Effect on phase 2? Conduction rate? Refractory period? Upstroke?
- Misc?
- Class 4 anti arrhythmic
- Increases refractory period
- Slows upstroke
- Slow AP's
27
Dilitiazam:
- Type of drug?
- M of A?
- Effect on phase 2? Conduction rate? Refractory period? Upstroke?
- Misc?
- Class 4 anti arrhythmic
- Increases refractory period
- Slows upstroke
- Slow AP's
28
Adenosine:
- Type of drug?
- M of A?
- Effect on phase 2? Conduction rate? Refractory period? Upstroke?
- Misc?
- Class x anti arrhythmic
- A1 adenosine receptor antagonsit
- Decrease Ifunny, and CaL; increase K+
- Lowers SA/AV firing rate
- Slow AP's
29
Atropine
- Inotropic Drug
- Blocks M2 and increases rate of slow AP
- Decreased vagal effect
30
Isoproteronol
- Inotropic drug
| - B1 agonist which increases AC conduction and rate
CVPR Unit 1
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