Drugs

Question 1

Prostaglandins

• Agent type
• PGE2 gel drug?
• PGE1 systemic drug?

Answer 1

• Labor induction
• Dinoprostone
• Misoprostol

Question 2

Oxytocin

• Agent type
• Route?
• Use (2)

Answer 2

• Labor induction
• IV/IM
• Labor induction after cervical ripening (not cervical dilation); post partum hemorrhage

Question 3

Methylergonovine

• Agent type
• Route?
• Use

Answer 3

• Labor induction
• Oral/IM
• Second line for post partum hemorrhage

Question 4

Nifedipine

• Agent type
• Route?

Answer 4

• Labor inhibition

- Oral

Question 5

Terbutaline

• Agent type
• MOA?

Answer 5

• Labor inhibition

- B2 receptor agonist relax SM

Question 6

Magnesium Sulfate

• Agent type
• MOA?
• Also used for?
• Side effects

Answer 6

• Labor inhibition
• Calcium channel block
• HELLPS
• Pulmonary edema, hypotension, muscle paralysis, respiratory arrest

Question 7

Indomethacin

• Agent type
• MOA
• Side effect

Answer 7

• Labor inhibition
• NSAID
• Pulmonary hypertension

Question 8

Ethanol

• Agent type
• MOA

Answer 8

• Labor inhibition

- Inhibits release of oxytocin

Question 9

Methotrexate

• Agent type
• MOA

Answer 9

• Abortant

- Folic acid antagonist

Question 10

Misoprostol

• MOA
• Use?
• Side effects

Answer 10

• PGE analogue
• Induce labor
• Diarrhea

Question 11

Mifepristone

• MOA
• Use?
• Side effects

Answer 11

• Progesterone receptor antagonist
• Induce labor
• Heavy bleeding, GI issues, abdominal pain

Question 12

Sildenafil/Vardenafil/Tadalafil

• Onset
• MOA
• Use?
• Side effects

Answer 12

• Within 1 hour; T=2hrs
• PDE inhibitor; increase CGMP; SM relaxant
• ED
• HA; dyspepsia; hypotension (except T); blue/green color blindness (S)