What is hypothalamus connected with
hypothalamus has reciprocal connections with forebrain limbic structures
And with brainstem and sc
Also controls output pituitary gland
what is hypothalamus key node in
pathways concerned with autonomic, endocrine, somatic and motivation functional concerned with maintained of homeostasis
= physiological states
Master controller of things that control tehse states
what does hypothalamus do = body temp ex
Hypothalamus determines deviation of internal body state from set point
(37c for body temp)
Initiates autonomic-endocrine bevahiorual responses to correct errro
what does hypothalamus do = body temp ex = inputs
huge amount sensory input
= temperature sensors (body sensors and also neurons in hypothalamus that are sensitive to temp)
Then = compares to internal set point of hypothalamus (differential amplifier - if deviation = outputs to bring temp back to set point)
what does hypothalamus do = body temp ex = outputs generally and what happens
If cold
1= to pituitary gland = release hormone, like thyroxin
2= to brainstem = control regions —> control ans = physiological and autonomic responses/reflexes - shivering, changes in blood flow
3= connections with cortex = influences behaviour = put on sweater
what does hypothalamus do = body temp ex = when sick and fever
Fever —> immune system acts on hypothalamus to increase step point - now 40c
So get chills, and shiver and body temp rises to new set point
After fever breaks — sweat bc now too hot compared to set point
where does hypothalamus project
Autonomic neurons and cpgs in brainstem and sc to coordinate autonomic reflexes and stereotyped behaviours involved in drive related responses and homeostatic control
Hierarchical organization of Outputs related to automatic outputs related to homeostasis
what brainstem structures involved - hypothalamus
Nucleus of solitary tract
Parabrachial nucleus
And pag
= regions involved in interception - involved in response to threats to homeostasis
what does hypothalamus coordinate
Responses which are expressed
But responses themselves are organized in brainstem structures
Ex = scared cat = pag coordinates pilo erection, hissing and arching of back
define amygdala
Key interface bewteen autonomic response, emotions, conscious feeling and their relation to leaning
Fear Learning
where is amygdala
Anterior to hippo
Inside medial temporal lobe = inside uncus
where is hippocampus
Medial region temporal lobe
Parahippocampal gyrus
describe conditioned fear leaning paradigm
Rat hears tone followed by foot shock
Animals learn very fast
describe conditioned fear leaning paradigm= after association what happens
Tone elicits physiological and behavioural responses related to fear and arousal
Learning doesn’t happen in amygdala lesions
describe conditioned fear leaning paradigm= describe control
measure hr = measure something physiological = arousal
After pairing a few time s= learns tone predicts foot shock
Make neutral stimulus become associated with physiological response
describe conditioned fear leaning paradigm= describe amygdala lesion
If bilateral lesion
= impeded classical conditioning response
Tone doesn’t elicit physiological responses
No more association
what does amygdala receive (conditioned fear leaning paradigm)
Receives sensory info about tone and shock from cerebral cortex and from thalamus directly
what does amygdala do (conditioned fear leaning paradigm)
Synaptic plasticity in amygdala links tone to shock
Directs learned behavioural (via pag) and physiological (via autonomic and endocrine systems) responses to tone
what does amygdala do (conditioned fear leaning paradigm)= describe whole pathway
2 stimuli = tone and shock, both get to amygdala via pathways
Direct = thalamus —> amygdala
Or
Indirect= thalamus —>cortex —> amygdala
In amygdala = highly plastic neurons and makes associations
Then pag and hypothalamus (autonomic system and pituitary)
Modulates physiology
humans with amygdala lesions
Similar deficits to ppl with vmpfc lesions
Also have abnormal learning
humans with amygdala lesions - ex = response
Don’t show expected physiological/emotion responses (changes in hr, bp, skin conductance) to pics of faces expression various emotion s
Traumatic images,should elicit strong physiological responses - increase in arousal but doesn’t
humans with amygdala lesions - ex = remember
Don’t remember emotionally charged pics or emotionally charged stories better than emotionally neutral pics/stories
Exp = show pics - neutral images and mix in emotional ones and then test later = if normal = remember emotional pics better but if amygdala lesion = don’t
humans with amygdala lesions - compare to vmpfc functions
Vmpfc = essential for linking emotions and learning to abstract social constructs/concepts
Like fear of taking exam, getting married
Vmpfc = link feeling to constructed values, more abstract
Amygdala = more just fear, sub cortical structures = need for fear response, more automatic
humans are
Moral reasoners
= make decision for moral reasons