hematology
Study of blood and blood forming tissues
Key components of hematologic system are:
- Blood
- Blood forming tissues
- Bone marrow
- Spleen: filters blood
- Lymph system: excretes copnents
What Does Blood Do?
Transportation
- Oxygen
- Nutrients
- Hormones
- Waste Products
Regulation
- Fluid, electrolyte
- Acid-Base balance
Protection
- Coagulation
- Fight Infections
erythropoiesis
= RBC production
- Stimulated by hypoxia
- Controlled by erythropoietin
+ Hormone synthesized in kidney
Hemolysis
Leukocytes/White Blood Cells
5 types
- Basophils
- Eosinophils
- Neutrophils
- Monocytes
- Lymphocytes
Diagnostic Procedures
Blood Work
- CBC
- Clotting Factors
Radiologic Studies
- CT/MRI of lymph tissues
Biopsies
- Bone Marrow examination
- Lymph node biopsies
wbc
Normal 4,000 -11,000 µ/ℓ
Associated with infection, inflammation, tissue injury or death
Leukopenia-
decrease WBC
Neutropenia
decrease neutrophil count
rbc
♂ 4.5 – 5.5 x 106/ℓ
♀ 4.0 – 5.0 x 106/ℓ
Hematocrit (Hct)
The hematocrit is the percent of whole blood that is composed of red blood cells. The hematocrit is a measure of both the number of red blood cells and the size of red blood cells.
platelet count
150,000-400,000
- thrombocytopenia- decrease platelet count
- spontaneous hemorrhage likely when count is below 20,000
pancytopenia
decrease in number of rbc, wbc, and platelets
Blood and Blood Product Transfusions
standard donation
Transfusion from compatible donor blood.
Autologous transfusions:
The client’s blood is collected in anticipation of future transfusions (elective surgery).
- up to 6w before surgery
Intraoperative blood salvage:
Blood loss during some surgeries (trauma-related, liver transplantation) is recycled through a device that filters blood into a transfusion bag for transfusion intraoperatively or postoperatively.
Excessive blood loss
packed RBCs
Anemia
packed RBCs
Kidney failure
packed rbc
Coagulation factor deficiencies such as hemophilia
fresh frozen plasma
Thrombocytopenia/platelet dysfunction:
platelets
Hemophilia A:
cryoprecipitate
Burns, hypoproteinemia
albumin