HRP

Question 1

Describe the key histological features of the vas deferens

Answer 1

• Thick walled muscular tube
• Epithelial lining- pseudostratified columnar
• Layers of longitudinal and circular smooth muscle - inner and outer are longitudinal, intermediate is circular
• Lumen stellate in shape (like a star)

Question 2

Key histological features of the prostate

Answer 2

• The prostate gland is made up of glands and stroma (supporting tissue)
• Serous alveoli with very much infolding of epithelium
• Fibromuscular stroma with descrete bundles of smooth muscle fibers
• Amorphous eosinophilic masses, called coprora amylacea, in the alveoli in older men

Question 3

Key histological features of the testis

Answer 3

• Convoluted (folded) semineferous tubules cut in various planes of section
• 4-8 layers of germ cells occupying the space between the basement membrane and the lumen
• Spermatozoa in the lumen and leydig cells in the interstitial spaces between the tubules
• Progression of development towards the lumen (from spermatogonia A or B to Spermatozoa (mature))

Question 4

What is the Rete testis? What does it look like histologically?

Answer 4

A network of small tubes in the testicle that helps move sperm cells (male reproductive cells) from the testicle to the epididymis.

Histology:

• Plexiform arrangement of channels
• Highly vascular collagenous connective tissue containing myoid cells
• Single layer of cuboid epithelial cells with microvilli and single cilium - cilia help aid the progress of spermatozoa
• Myoid cell contraction
• Epithelium reabsorbs protein and potassium

Question 5

Key histological features of the Epididymis

Answer 5

• No progression of development towards the lumen
• A number of tubules in varied section
• Lining of the epithelium is pseudostratified tall columnar with long microvilli inappropriately called non-motile cilia (sterecilia)
• Lumina usually contain bunches of spermatozoa (sperm is stored here)

Question 6

Histology of seminal vesicle

Answer 6

• Epithelial lining- Pseudostratified tall columnar
• Secretary cells with lipid droplets in the cytoplasm
• The lumen of seminal vesicle is highly irregular – Honeycombed appearance

Question 7

Endometrial polyp

Answer 7

Question 8

Ovarian carcinoma

Answer 8

• Large ovaries
• Thickened external (Serosal) surface

Question 9

Uterine Leiomyoma / Uterine fibroids

Answer 9

• Benign smooth muscle growths of the uterus that often appear during childbearing years.
• Have a defined edge to them
• Develop in the myometrium

Question 10

In which phase of the menstrual cycle are there mitoses in the endometrial epithelium?

Answer 10

Proliferative/follicular

• Straight glands

Question 11

In which phase of the menstrual cycle are there vacuoles in the endometrial epithelium?

Answer 11

Secretory / luteal phase

• tortuous and dilated glands

Question 12

What is this MRI showing?

Answer 12

A pathology in the seminal vesicle

Question 13

Prostatitis histology

Answer 13

• Macrophages in stroma (purple)
• Lymphoid aggregates are not specific for prostatitis

Question 14

Prostatic adenocarcinoma histology

Answer 14

Pseudoacinar spaces - may be crowded but even still a bit of stroma separates them.

Question 15

Testicular Seminoma

Answer 15

Question 16

Histology of the ovary

Answer 16

• Outer cortex and inner vascular medulla
• Parenchyma contains numerous ovarian follicles in various stages of development
• F = Follicle
• CL = Corpus luteum
• M = medulla
• Ft = fallopian tube
• A = corpus albicans

Question 17

Histology of secondary follicle

Answer 17

• O1 - Primary oocyte
• CO – Cumulus oophorus
• TE – Theca externa
• ZG – Zona granulosa
• FA- Follicular antrum
• T1 – Theca interna

Question 18

Histology of Graffian follicle

Answer 18

• O2 – Secondary oocyte
• ZG – Zona granulosa
• CR - Corona radiate
• T1 – Theca interna
• FA- Follicular antrum

Question 19

Histology of the breast tissue during pregnancy

Answer 19

Question 20

Histology of the breast tissue during lactation

Answer 20