1
Q
Difference between Cohn’s and Ulcerative?
A
Cohn’s = segmented inflammation of deep tissue layer from mouth to anus
-abdominal pain, diarrhoea, malnutritionm, haemorrhoids
Ulcerative = inflammation of superfical tissue on one area, generally on colon/rectum
-bloody stools, weight loss, fatigue, low haemoglobin (bleeding)
2
Q
What are some risk factors for IBD?
A
Oxidative stress, genetics, sleep disturbances, smoke, bade microbiome, opioids make it worse
3
Q
Sulfazalazine
MOA
A
5-ASA (aminosalicylate-derivative)
- converted by but bacteria in mezalazine
- has a local effect on GI tract
- metabolised by NAT-1 into something that can cause
- decrease PG synthesis
- decrease chemotaxis
- decrease leukotriene sythnesis
4
Q
Mesalazine
A
5-ASA (aminosalicylate-derivative)
- has a local effect on GI tract
- metabolised by NAT-1 into something that can cause
- decrease PG synthesis
- decrease chemotaxis
- decrease leukotriene sythnesis
5
Q
Azathiopurine
MOA
A
Purine antimetabolite
- prodrug of mercaptopurine
- binds to HGRPT
- prevents recycling/production of purines
